What is KCentra used for?

KCENTRA®, Prothrombin Complex Concentrate (Human), is a blood coagulation factor replacement product indicated for the urgent reversal of acquired coagulation factor deficiency induced by Vitamin K antagonist (VKA—eg, warfarin) therapy in adult patients with acute major bleeding or the need for urgent surgery or other …

How do you administer warfarin?

Warfarin comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take warfarin at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand.

How do you bridge warfarin?

Bridging Unfractionated Heparin, LMWH, or Fondaparinux to Warfarin. In the treatment of VTE and pulmonary embolism, the parenteral anticoagulant should be overlapped with warfarin for a minimum of five days. In most cases, warfarin can be initiated on day 1, after the first dose of the parenteral agent has been given.

How do you administer FEIBA?

Infusing FEIBA [Anti-Inhibitor Coagulant Complex] with a syringe pump helps your patients control the infusion rate and provides a hands-free experience. Maximum injection or infusion rate must not exceed 2 units per kg of body weight per minute.

How do you mix Kcentra?

Reconstitute Kcentra using aseptic technique with 20 mL (nominal potency 500 U kit) or 40 mL (nominal potency 1000 U kit) of Sterile Water for Injection (diluent) provided in the kit. Do not use Kcentra beyond the expiration date on the vial label and carton. Kcentra is for single use only. Contains no preservatives.

Is Kcentra a FFP?

Conventionally, fresh frozen plasma (FFP) is used for reversal of INR in patients with major bleeding or who need urgent surgery or invasive procedures. Kcentra is now available as an alternative to FFP for rapid reversal of INR and urgent hemostasis.

How do you restart warfarin?

Upon restarting warfarin in the setting of known prior maintenance dosing, use of higher warfarin doses (about 1.5 times the usual maintenance dose) for 2 or 3 days, followed by step-down to the maintenance dose, expedites the achievement of a therapeutic INR.

How do you reconstitute FEIBA?

Turn the device over so that the diluent vial is on top. Slowly press plunger to inject all air back into vials. This will force diluent into the bottom vial. Swirl gently until FEIBA is completely dissolved.

Is Kcentra compatible with normal saline?

After KCentra® dose is complete, administer a 50 mL bag of normal saline using the same IV tubing at the same rate as KCentra® dose to ensure administration of full dose.

What color tube is used for INR?

ORDERING INFORMATION: Geisinger Epic Procedure Code: LAB2946 Geisinger Epic ID: 14539
Specimen type: Platelet-poor plasma
Preferred collection container: 2.7 mL blue-top (3.2% sodium citrate) tube
Alternate Collection Container: Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)

When do you bridge warfarin PE?

When warfarin is used to treat an acute deep vein thrombosis (DVT) or pulmonary embolism (PE), a bridge with a parenteral anticoagulant is absolutely necessary for 2 reasons: Warfarin takes about 5 days to achieve full anticoagulation (INR above 2).

Why do you bridge warfarin with heparin?

Therefore, heparin is often used as a “bridge” when initiating warfarin therapy in patients with AF, not only because physicians feel a need to begin anticoagulation as soon as possible for stroke prevention but also because they want to protect patients from this presumed transient hypercoagulable state.