What is intrathecal methotrexate used for?

Methotrexate is a chemotherapy drug that is used to treat certain types of cancer and leukaemia. When given intrathecally, it prevents leukaemia cells entering the cerebrospinal fluid (CSF) around the spine and brain. It is also used to treat leukaemia found in the CSF.

What is the purpose of intrathecal chemotherapy?

Intrathecal (IT) chemotherapy is used to treat cancers that have entered into the CSF. When a cancer has gotten into the CSF, it may be called CNS (central nervous system) involvement.

Where is intrathecal injection given?

Once your skin is numb, the anesthesiologist places a special needle into your back and into the spinal space. This space is just outside the spinal cord. He or she will inject the medicine into this space.

What cancers does methotrexate treat?

Methotrexate is also used to treat certain types of cancer including cancers that begin in the tissues that form around a fertilized egg in the uterus, breast cancer, lung cancer, certain cancers of the head and neck, certain types of lymphoma, and leukemia (cancer that begins in the white blood cells).

How is intrathecal chemotherapy performed?

A healthcare professional will administer intrathecal chemotherapy by injecting it into the spinal canal during a lumbar puncture. They may also administer it through a plastic insert called an Ommaya reservoir, which sits under the scalp.

Which needle used for intrathecal?

A 25-gauge needle, about 1 cm long, is usually used and is inserted at a 10- to 15-degree angle to the skin.

Is methotrexate a strong chemo?

When used for inflammatory arthritis, methotrexate is not considered chemotherapy. It is considered a DMARD (Disease modifying anti-rheumatic Drug).

What drugs are given intrathecally?

Currently there are only three medications approved by the US Food and Drug Administration (FDA) for use via the intrathecal route, ie, morphine, ziconotide, and baclofen. Morphine targets opioid receptors within the dorsal horn.

Is epidural same as intrathecal?

Intrathecal administration is delivered directly into the CSF and into the superifical spinal cord; epidural administration diffuses through the dura into the CSF, and thus has a slower onset of action.

How long does intrathecal chemotherapy last?

The process takes about 30 minutes. Afterward, you’ll stay still for at least an hour to let the drug move through the intrathecal space. If you need many doses or will get your medicines over a long period, your doctor may suggest an implant so you don’t need as many spinal taps.

Who can give intrathecal chemotherapy?

4.1. Intrathecal chemotherapy should be approved and prescribed only by Consultant Haematologists, Staff Grade or Associate Specialist Haematologists who are authorised by the Lead Clinician for this specific area of clinical practice (Appendix 1).

¿Qué es la quimioterapia intratecal?

La quimioterapia intratecal se administra durante un procedimiento llamado punción lumbar o a través de un depósito de Ommaya (shunt). Antes de recibir la quimioterapia TI, se le hará un análisis de laboratorio. Es necesario tener un recuento de plaquetas suficiente para asegurar que su sangre coagule en el sitio después del procedimiento.

¿Qué es la quimioterapia intralesional?

Quimioterapia intralesional Se introduce una aguja para administrar el medicamento directamente en el tumor. Esto es posible solamente cuando la aguja puede alcanzar al tumor de forma segura. Quimioterapia intravesical La quimioterapia se administra directamente en la vejiga a través de un catéter blando

¿Cómo se hace la quimioterapia?

Introducirá una aguja en los espacios entre su columna (LCR) e inyectará la quimioterapia. Podría tomar de 10 a 30 minutos para terminar la inyección. Cuando la inyección esté completa, él sacará la aguja y cubrirá el área con un vendaje. Usted necesitará acostarse boca arriba por 30 a 60 minutos después del procedimiento.

¿Cómo se hace la quimioterapia en la espalda?

La inyección usualmente se administra en la parte inferior de su espalda. Antes de una punción lumbar, su médico entumecerá el área. Él también podría administrarle medicamento por vía intravenosa para ayudarlo a relajarse. Introducirá una aguja en los espacios entre su columna (LCR) e inyectará la quimioterapia.