What does focal high-grade prostatic intraepithelial neoplasia mean?

HGPIN refers to proliferation of prostate glandular epithelial cells that display significant cytological atypia within the confines of prostatic ducts and acini. 2. It has been accepted as the main precursor lesion to invasive prostate carcinoma.

What does prostatic intraepithelial neoplasia mean?

Prostatic intraepithelial neoplasia (PIN) is a condition “defined by neoplastic growth of epithelial cells within preexisting benign prostatic acini or ducts.”3 Because PIN satisfies almost all the requirements for a premalignant condition, high-grade PIN (HGPIN) is widely accepted as a precursor to prostate cancer.

What is the treatment for high-grade prostatic intraepithelial neoplasia?

In this setting, some doctors will recommend treatment, such as surgery or radiation, since intraductal carcinoma is typically associated with high-grade prostate cancer. Other doctors may choose to do a repeat biopsy to try to confirm the high-grade cancer before starting treatment.

What is foci in prostate cancer?

The presence of two or more prostate cancer foci separated by intervening benign tissue in a single core is a well-recognized finding on prostate biopsy. Cancer involvement can be measured by including intervening benign tissue or only including the actual cancer involved area.

What is neoplasia mean?

Neoplasia (nee-oh-PLAY-zhuh) is the uncontrolled, abnormal growth of cells or tissues in the body, and the abnormal growth itself is called a neoplasm (nee-oh-PLAZ-m) or tumor. It can be benign (bee-NINE) or malignant.

How do you treat a high-grade PIN?

Current treatment options

  1. Androgen-deprivation therapy. Some studies of men with both high-grade PIN and prostate cancer who underwent treatment for the cancer have concluded that androgen-deprivation therapy reduced the extent of high-grade PIN.
  2. Finasteride (Proscar).
  3. Other options.
  4. Originally published Oct.

What are the stages of prostate cancer?

Stages of prostate cancer

AJCC Stage Stage grouping
IIC T1 or T2, N0, M0 Grade Group 3 or 4 (Gleason score 4+3=7 or 8) PSA less than 20
IIIA T1 or T2, N0, M0 Grade Group 1 to 4 (Gleason score 8 or less) PSA at least 20
IIIB T3 or T4, N0, M0 Grade Group 1 to 4 (Gleason score 8 or less) Any PSA

How long can you live with Gleason 7 prostate cancer?

Maximum estimated lost life expectancy for men with Gleason score 5 to 7 tumors was 4 to 5 years and for men with Gleason score 8 to 10 tumors was 6 to 8 years.

Are neoplasms always cancerous?

Neoplasms may be benign (not cancer) or malignant (cancer). Benign neoplasms may grow large but do not spread into, or invade, nearby tissues or other parts of the body. Malignant neoplasms can spread into, or invade, nearby tissues.

Does Gleason 7 require treatment?

In contrast, patients with Gleason 7 to 10 cancer should consider treatment (i.e., radical prostatectomy or radiation). These patients have a high risk of dying from prostate cancer, and disease-free survival appears to be better after treatment.

What is the pattern of high-grade prostatic intraepithelial neoplasia?

High-grade prostatic intraepithelial neoplasia, micropapillary pattern (hematoxylin & eosin, × 400). Open in a separate window Figure 3 High-grade prostatic intraepithelial neoplasia, cribiform pattern (hematoxylin & eosin, × 200). Open in a separate window Figure 4

What is prostatic intraepithelial neoplasia (pun)?

Brawer MK, Rennels MA, Nagle RB, et al. Prostatic intraepithelial neoplasia: a lesion that may be confused with cancer on prostatic ultrasound. Urol. 1989;142:1510–1512.

Is prostatic intraepithelial neoplasia a precursor to prostate cancer?

High-grade prostatic intraepithelial neoplasia (PIN) is most likely a precursor of prostate cancer and is frequently associated with it, whereas the direct link between low-grade PIN and cancer is not established.

What are the patterns of prostatic intraepithelial neoplasia (PIN)?

Prostatic intraepithelial neoplasia (PIN), characterized by cellular proliferations within preexisting ducts and acini with cytologic changes mimicking cancer, has been shown to follow 4 main patterns: tufting, micropapillary, cribriform, and flat. These patterns appear to be of diagnostic utility only.