How is tropical sprue different from celiac?
Tropical sprue is a malabsorption disease commonly found in tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine. It differs significantly from coeliac sprue. It appears to be a more severe form of environmental enteropathy.
What are the histopathological features of celiac disease?
Typically, coeliac disease is characterised by the triad of histological features: 1) intraepithelial lymphocytosis (IEL>30/100 epithelial cells), 2) lamina propria inflammation, and 3) villous atrophy.
What is celiac disease pathology?
Celiac sprue / celiac disease (gluten sensitive enteropathy) is an immune mediated inflammatory disease of the small intestine seen in genetically predisposed individuals and is caused by sensitivity to prolamins, like wheat (gliadin), Barley (hordein), rye (secalin) and oats (avenin)
Why is there crypt hyperplasia in celiac disease?
Crypt hyperplasia is when the grooves are elongated compared to a normal intestinal lining which has short crypts. Blunted or atrophic villi. This is a shrinking and flattening of the villi due to repeated gluten exposure. Mononuclear cell infiltration in the lamina propria.
What is tropical sprue?
Tropical Sprue is a rare digestive disease in which the small intestine’s ability to absorb nutrients is impaired (malabsorption). Consequently, nutritional deficiencies and abnormalities in the mucous lining of the small intestine may be present.
How is tropical sprue diagnosed?
Tropical sprue is a rare acquired disease, probably of infectious etiology, characterized by malabsorption and megaloblastic anemia. Diagnosis is clinical and by small-bowel biopsy. Treatment is with tetracycline and folate for 6 months.
Does a biopsy confirm celiac disease?
Endoscopies and biopsies are the best way to diagnose celiac disease. A gastroenterologist (doctor who treats people with disorders of the stomach and intestines) will do an endoscopy if your/your child’s blood tests or genetic tests show signs of celiac disease.
Is sprue the same as celiac disease?
Celiac disease, sometimes called celiac sprue or gluten-sensitive enteropathy, is an immune reaction to eating gluten, a protein found in wheat, barley and rye. If you have celiac disease, eating gluten triggers an immune response in your small intestine.
How is tropical sprue caused?
The exact cause of Tropical Sprue is not known. It is an acquired disorder that may be related to environmental and nutritional factors, or Tropical Sprue may be related to an infectious organism (either viral or bacterial), dietary toxin, parasitic infestation, or a nutritional deficiency such as folic acid.
Who gets tropical sprue?
Only rare cases of tropical sprue have been reported in the United States. The disease affects indigenous populations as well as visitors to the tropics who stay for more than a month. Tropical sprue is seldom seen in travelers who visit an endemic area for less than two weeks.
What sprue means?
1 : the waste piece on a casting (as of metal or plastic) left by the hole through which the mold was filled. 2 : the hole in which a sprue forms. sprue.
How tropical sprue can cause anemia?
The anemia of tropical sprue is most often macrocytic and related to vitamin B12 and folate malabsorption. Iron deficiency may also occur, related to malabsorption, and may turn a macrocytic anemia into a normocytic anemia.
Why is it called a sprue?
The name sprue derives from a Dutch word describing inflammation of the mouth, which is a frequent symptom. The disease has been recognized for more than 2000 years. It occurs mostly, but not exclusively, in the tropics. Symptoms and Treatment.
Are basal cells ciliated?
Normal basal cells not only have the ability to proliferate and generate differentiated secretory and ciliated cells, but they also secrete proteins that can influence their neighbor cells and have receptors that can be influenced by products from other cells (39, 44, 45).